While breast cancer survival continues to improve, thanks to advances in detection and treatment, when breast cancer recurs – or returns after initial treatment – it is incurable.
Reviewed by Lily Ramsey, LLMOct 24 2023 Currently, there is no way to predict who is most likely to experience a breast cancer recurrence, and for the 30 percent of women and men who do relapse, continuous and indefinite treatment is the only option for attempting to slow the cancer growth.
Dormant tumor cells were successfully cleared from more than 80 percent of patients across all three arms of the study, principal investigator Angela DeMichele, MD, MSCE, FASCO, the Alan and Jill Miller Professor in Breast Cancer Excellence, reported today at the European Society for Medical Oncology Congress 2023.
"The dormant/latency phase is an opportune window to intervene because we've found that these dormant cells are sensitive to drugs that don't work against actively growing cancer cells," Chodosh said. "Contrary to current thinking, drugs that are not effective against metastatic disease may be highly effective when used during the dormant phase of disease."
The breast cancer survivors in the study had all completed their cancer treatment within the last five years at the time of study enrollment and were randomized to receive one of three drug therapy regimens. Nearly half of the patients in the study had triple-negative breast cancer, which has a historic recurrence rate of 30 percent within the first five years.
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