Doctors successfully treated a patient's rare brain infection with a drug typically used for UTIs.
A decades-old drug for urinary tract infections may also work for"brain-eating" amoeba infections, which kill the vast majority of people who contract them, Science magazine reported .
The drug's promise was demonstrated in a recent case report, published in January in the journal Emerging Infectious Diseases , which describes a 54-year-old man whose brain was infiltrated by the amoeba Balamuthia mandrillaris. The single-celled organism lives in dust, soil and water, and can enter the body through skin wounds and cuts or through the lungs, when it's inhaled, according to the Centers for Disease Control and Prevention .
"The disease might appear mild at first but can become more severe over weeks to several months," the CDC notes. The man in the case report initially received treatment at a Northern California hospital for an unexplained seizure. Magnetic resonance imaging revealed a mass on the left side of his brain, surrounded by swelling. At this point, the man was transferred to the University of California San Francisco Medical Center, where doctors took samples of the patient's brain tissue and the clear fluid surrounding the brain and spinal cord. This analysis revealed B. mandrillaris in the man's brain.
The patient was soon discharged from the hospital and he continued to take nitroxoline at home, along with other medications; his clinicians plan to eventually discontinue his use of the drugs. In the meantime, UCSF doctors are overseeing the case of a second B. mandrillaris-infected patient who's started receiving nitroxoline. They are seeing similar improvements, Science reported.
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