Using engineered microbes as microscopic factories has given the world steady sources of life-saving drugs, revolutionized the food industry, and allowed us to make sustainable versions of valuable chemicals previously made from petroleum. But behind each biomanufactured product on the market today is the investment of years of work and many millions of dollars in research and development funding. Scientists want to help the burgeoning industry reach new heights by accelerating and streamlining the process of engineering microbes to produce important compounds with commercial-ready efficiency.
Using engineered microbes as microscopic factories has given the world steady sources of life-saving drugs, revolutionized the food industry, and allowed us to make sustainable versions of valuable chemicals previously made from petroleum.
A team led by senior scientist Aindrila Mukhopadhyay has developed a workflow that combines CRISPR gene editing with a suite of computational models of microbial gene expression and enzyme activity that can be used to predict the necessary gene edits. Their latest work was recently published in"Much of strain design is still trial-and-error based, which is laborious and time consuming.
The team started out with a strain of bacteria that can naturally feed on a derivative of lignin, then used PSP to investigate which native genes needed to be deleted, what non-native genes needed to be inserted, and what culturing conditions were needed for the bacteria to produce high levels of a non-native compound. Thousands of computational designs were evaluated and eventually two were tested in the lab.
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