Clinicians at Georgetown University's Lombardi Comprehensive Cancer Center reported promising preliminary findings based on outcomes in the first six patients with metastatic pancreatic cancer enrolled in a phase 2 clinical trial of the experimental drug BXCL701 in combination with the immunotherapy drug pembrolizumab (Keytruda).
Jun 3 2024Georgetown University Medical Center Clinicians at Georgetown University's Lombardi Comprehensive Cancer Center reported promising preliminary findings based on outcomes in the first six patients with metastatic pancreatic cancer enrolled in a phase 2 clinical trial of the experimental drug BXCL701 in combination with the immunotherapy drug pembrolizumab . Immunotherapy drugs alone have not shown to be responsive to pancreatic cancer .
Pancreatic cancer is the third leading cause of cancer death. The 5-year survival rate for all stages of the disease is 13% but there's no early detection method and therefore patients are often diagnosed with later stage disease. For those with disease that has spread beyond the pancreas, the 5-year survival rates are an extremely low 3%.
In pre-clinical mouse studies, published in 2021, researchers led by Louis Weiner, MD, director of Georgetown University's Lombardi Comprehensive Cancer Center, showed that when combined with an immunotherapy drug, BXCL701 boosted the animals' natural immune systems, slowing or even stopping pancreatic tumor growth.
According to Weinberg, the main side effect so far is low blood pressure, which can be mitigated by giving BXCL701 at a lower dose during the first week of treatment. The clinicians are also seeing anemia, nausea, and immune-related arthritis, which has responded to oral steroids.
Clinical Trial Pancreatic Cancer Chemotherapy Drugs Food Imaging Immune System Immunotherapy Leukemia Medicine Melanoma Oncology Pancreas Research Sarcoma Soft Tissue Sarcoma Therapeutics Tumor
日本 最新ニュース, 日本 見出し
Similar News:他のニュース ソースから収集した、これに似たニュース記事を読むこともできます。
West Coast Conference adding Grand Canyon University, Seattle University in 2025GCU and Seattle will both compete in 14 of the WCC’s sponsored sports.
続きを読む »
Leaders of Northwestern, UCLA, and Rutgers to Testify Before Congress on Campus ProtestsHouse Republicans have summoned the leaders of Northwestern University and Rutgers University to testify.
続きを読む »
Experimental therapy shows promise in pancreatic cancer clinical trialClinicians at Georgetown University's Lombardi Comprehensive Cancer Center reported promising preliminary findings based on outcomes in the first six patients with metastatic pancreatic cancer enrolled in a Phase II clinical trial of the experimental drug BXCL701 in combination with the immunotherapy drug pembrolizumab (Keytruda).
続きを読む »
England team news 'leaked' ahead of Bosnia friendly with Gareth Southgate set to play experimental sideEngland face Bosnia and Herzegovina in a friendly clash ahead of Euro 2024.
続きを読む »
Researchers develop experimental mRNA avian flu vaccineAn experimental mRNA vaccine against avian influenza virus H5N1 is highly effective in preventing severe illness and death in preclinical models.
続きを読む »
Pfizer pauses trial for experimental gene therapy drug after child participant dies suddenlyThe boy, who was aged between two and four, suffered a cardiac arrest after receiving the one-off gene therapy last year. It was poised to become one of the world's most expensive drugs.
続きを読む »