Experimental HIV Vaccine Successfully Triggers Potent Antibodies in Humans

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Experimental HIV Vaccine Successfully Triggers Potent Antibodies in Humans
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in the immunized – antibodies that are primed to neutralize subsequent intruders. For a vaccine to be safe, it has to do so for the vast majority without major side effects or reactions.

Natural infections give us a sense of how difficult it is to get the immune system to make these potent antibodies: bnAbs only materialize in"It was very exciting to see that, with this vaccine molecule, we could actually get neutralizing antibodies to emerge within weeks,"The vaccine candidate targets HIV-1, the most common of the two types of HIV, and specifically, a part of its outer envelope that remains stable even as the virus mutates.

The long-sought-after elite neutralizers, bnAbs, were also generated in two of the five people who received three shots before the trial was stopped. The most potent of those antibodies neutralized 15 to 35 percent of HIV strains in cell experiments.

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