In this interview, News Medical speaks to Isaac Chiu, Ph.D and Daping Yang, Ph.D. of Harvard Medical School, about their latest research, revealing the surprising properties of pain.
Interview conducted by Aimee MolineuxApr 2 2024 In this interview, News Medical speaks to Isaac Chiu, Ph.D., and Daping Yang, Ph.D. of Harvard Medical School, about their latest research, revealing the surprising properties of pain.Thought LeadersIsaac Chiu, Ph.D.Daping Yang, Ph.D.Harvard Medical School Please can you introduce yourself and tell us about your background, as well as what inspired you to conduct your latest research? Isaac Chiu, Ph.D.
Daping Yang, Ph.D. - My Ph.D. training focused on Immunology, and I started my postdoctoral work in Chiu Lab three years ago. I am very interested in how the homeostasis of our gut mucosal barrier system is maintained and how this system senses and adapts itself to the ever-changing environment. As we all know, patients with inflammatory diseases usually suffer from visceral pain, which we also noticed in our mouse colitis model in the lab.
Your latest research suggests that on top of being an alert system, pain also plays a direct protective role in the gut, shielding it from damage. Can you tell us more about how you conducted your study? To investigate the role of nociceptor neurons in the gut and host protection, we generated mice that lacked these pain-mediating neurons. As the mucus barrier is the first defense barrier of the gut mucosa, we first tried to measure the mucus layer thickness using immunostaining.
Related StoriesThese results suggest that nociceptor neurons might regulate goblet cell production through CGRP they produced. It also means mucus production is intimately associated with the nervous system. Another quite interesting finding is that the gut microbiome can regulate this process by stimulating nerves to release CGRP.
Your study also noted the possible downsides to suppressing pain. What are these downsides, and why is it so important to consider the possible consequences of blocking pain? Because we found that pain protects the gut by mediating mucus production and maintaining a healthy microbiome, if we suppress pain, it could interfere with this protective property. There are people who have headaches and migraines who are currently taking drugs to block CGRP or its receptor RAMP1.
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