Engineered Nanoparticles Form Nanoplatform to Target Glioblastoma: NanoLetters nanoparticles Glioblastoma nanomedicine cancer braincancer
By Bhavna KavetiAug 15 2022Reviewed by Susha Cheriyedath, M.Sc. Glioblastoma is the most common and highly malignant cancer in the adult brain, characterized by poor prognosis and aggressive infiltration. A long-standing problem in GBM treatment is the delivery of therapeutics to brain-invading tumor cells that is obstructed by the blood−brain barrier . Immune checkpoint blocker-based combination therapy stands critical for GBM treatment.
Nanoparticles for GBM Therapy GBM is an aggressive type of primary brain cancer, with a median survival of 12 months from the initial diagnosis. These invasive glioma cells can migrate extensively into the brain and are often resistant to therapy. Thus, GBM has a high level of reoccurrence and mortality. Collectively, the location and reoccurrence of GBM restrict the improvement in prognosis.
Therapeutic nanoparticles can control drug release kinetics, reducing the need for multiple administrations. Furthermore, nanoparticles can be formulated with multiple drugs for combination therapies. The physicochemical properties of nanoparticles dictate their ability to transport across or circumvent the BBB.
Although previous reports mentioned the ability of macrophages to express PD-1, these were unregulated in terms of TME-based response and pathogen infection. Moreover, lipopolysaccharide-stimulated macrophages showed 3.89-fold more PD-1 microRNA expression than unstimulated cells.
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