Eating grapes may reduce the risk of fatty liver disease FattyLiver Liver LiverDisease grapes metabolicdiseases RNAsequencing nutrigenomics longislandu MSKCancerCenter WNEUniversity Foods_MDPI
Study: Consumption of Grapes Modulates Gene Expression, Reduces Non-Alcoholic Fatty Liver Disease, and Extends Longevity in Female C57BL/6J Mice Provided with a High-Fat Western-Pattern Diet. Image Credit: EduardSV / Shutterstock
Grapes are considered wonder fruits. The bioactive components of grapes are known to modulate the pathophysiology of various diseases, including diabetes, obesity, cancer, and inflammatory diseases. In addition, grape components are also known to control the aging process and improve longevity. The scientists specifically aimed to understand the impact of grape consumption on hepatic gene expression, lipid metabolism, longevity, and non-alcoholic fatty liver disease. Mice fed with a 5% grape powder-supplemented high-fat diet or semi-synthetic diet were used as experimental models.
Furthermore, an enrichment in drug metabolism, detoxification, antioxidant, and oxidative stress-related pathways was observed in mice fed with a grape-supplemented standard diet. Glutathione-S-transferase P1 is an antioxidant enzyme and is commonly involved in these pathways.
The RNA-seq findings revealed differential expression of over 5600 genes between the two groups. Several of these genes are involved in reducing fatty liver, including mitochondrial and peroxisomal degradation, esterification, phospholipid metabolism, sequestration, and hydrolysis. Since a high-fat diet is known to reduce the lifespan in mice, the study also investigated the effect of grape supplementation on longevity. The findings revealed that lifetime dietary grape consumption is associated with significant improvement in survival.
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