Early data from coronavirus vaccine trials are encouraging, but there’s still a long way to go ForbesFrontlines
To address this question, let’s look at what a Phase I study is not. Generally, Phase I trials do not examine efficacy. In other words, we won’t know from these trials if the vaccines work. That’s another question for another trial. Instead, researchers conducting these studies asked three more basic questions.
It should be noted, though, that data from the mRNA-1273 trial have not been released. We have Moderna’s press release, but little else. In contrast, data from the Ad5-nCoV trial have been published. It also should be noted that the most encouraging part of the Moderna report is based on an early analysis of just eight “sentinel” participants. The trial has not yet been completed and a final analysis is not available.Phase 1 clinical trails explore the safety of a vaccine.
So, participants in both studies produced neutralizing antibodies. Does that mean that these individuals now are protected from future SARS-CoV-2 infections? No. To detect neutralizing antibodies, the scientists usedassays. SARS-CoV-2 was mixed with serum from a participant or a control solution. The treated virus then was added to mammalian cells grown in the laboratory. The number of cells that became infected was determined.
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