Mice given a dose of the hormone FGF21 recovered much faster, researchers found. They think it could be used to treat alcohol poisoning in people.
“We’ve discovered that the liver is not only involved in metabolizing alcohol but that it also sends a hormonal signal to the brain to protect against the harmful effects of intoxication, including both loss of consciousness and coordination,” study senior author and biochemist Steven Kliewer told Gizmodo. “We’ve further shown that by increasing FGF21 concentrations even higher by injection, we can dramatically accelerate recovery from intoxication.
Of course, these results are based on mice, so it’s possible that giving extra FGF21 to drunk humans wouldn’t provide the same dramatic benefit. But if more studies do support the team’s findings, including in humans, then FGF21 could very well emerge as a fast-acting treatment against life-threatening intoxication.
The team next plans to figure out the exact pathways in the brain that FGF21 activates when acting as a hormonal cold shower.
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