Drug clears sleeping sickness parasite from the body in clinical trial

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Drug clears sleeping sickness parasite from the body in clinical trial
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In a small trial, an experimental medicine was 100 per cent effective at ridding the parasite that causes sleeping sickness from the bodies of people with an early to intermediate infection

To test the potential of a one-off drug called acoziborole,at the Center for Neglected Diseases in Switzerland and his colleagues analysed 208 people over the age of 15 in the Democratic Republic of the Congo and Guinea. The participants were diagnosed with sleeping sickness between October 2016 and March 2019.

Acoziborole wasn’t compared against fexinidazole due to there being relatively few people in the study areas who had been diagnosed with sleeping sickness, says Tarral. The sample size in each treatment group would therefore have been too small to give a meaningful comparison, he says. If not treated properly, the parasite can linger and cross the blood-brain barrier, invading the central nervous system and causing severe symptoms.achieve its target to eliminate the transmission of a common form of sleeping sickness worldwide by 2030“This drug can change the world of this disease,” he says. Acoziborole could be available in two years, says Tarral.

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