People with subclinical hyperthyroidism are at 34% greater risk of experiencing a fracture compared with those with normal thyroid function, new research shows. MedTwitter
The vast majority of participants had normal thyroid function, 2.6% had subclinical hyperthyroidism, and 4.4% had subclinical hypothyroidism, according to the researchers.
Median follow-up was 21 years. The researchers identified 3556 incident fractures, detected with hospitalization discharge codes through 2019 and inpatient and Medicare claims data through 2018, for a rate of 167.1 per 10,000 person-years. Adjusted hazard ratios for fracture were 1.34 for people with subclinical hyperthyroidism and 0.90 for those with subclinical hypothyroidism, compared with those with normal thyroid function.Limitations included a lack of thyroid function data during the follow-up period and lack of data on bone mineral density, the researchers write.
The new paper underscores that subclinical hyperthyroidism "should be included as an important risk factor" for fracture as well as. In considering whether to treat osteoporosis, subclinical hyperthyroidism"may be enough to tip the balance in favor of pharmacological therapy," he added.
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