Researchers establish AnimalGAN as a reliable alternative for generating synthetic pathology data.
By Vijay Kumar MalesuNov 10 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in Nature Communications, researchers establish AnimalGAN as a reliable alternative for generating synthetic pathology data in an effort to ultimately reduce animal testing in drug safety assessments and accurately predict hepatotoxicity.
By facilitating extensive virtual experiments, AnimalGAN could improve predictions of rare toxicological events and enhance the translation from animal to human outcomes. However, further research is needed to improve its predictive accuracy and solidify the role of AnimalGAN as a reliable alternative to animal testing.
AnimalGAN was trained on data from 8,078 rats, with 80% for training and 20% for testing. This model aimed to replicate clinical measurements using metrics like valid blood cell counts, cosine similarity, and Root Mean Square Error for validation. Study findings AnimalGAN, a new model in computational toxicology, has demonstrated impressive capability by generating 38 clinical pathology metrics and mimicking complex biological responses to varied treatment lengths and doses. AnimalGAN was thoroughly trained on data from 6,442 rats across 1,317 distinct treatment scenarios with 110 compounds from the TG-GATEs database.
The performance of AnimalGAN was also compared to that of conventional artificial intelligence methods, like quantitative structure-activity relationship models, which are typically modeled to predict each clinical pathology measurement separately. Comapratveiyl, AnimalGAN was associated with the impressive ability to simultaneously predict all 38 measurements with greater accuracy, thus highlighting its advanced predictive prowess as compared to traditional models.
日本 最新ニュース, 日本 見出し
Similar News:他のニュース ソースから収集した、これに似たニュース記事を読むこともできます。
Researchers identify brain network that is uniquely activated through injection vs. oral drug useResults from a new clinical trial suggest that a group of brain regions known as the 'salience network' is activated after a drug is taken intravenously, but not when that same drug is taken orally.
続きを読む »
Consuming flavonoids helps fight symptoms of endometriosis, researchers findResearchers at Texas A&M University's School of Veterinary Medicine and Biomedical Sciences (VMBS) have found a correlation between a compound found in fruits and vegetables and a reduction in the symptoms of endometriosis.
続きを読む »
Researchers receive funding to explore factors associated with brain health in female military veteransA pioneering multi-disciplined team of researchers from Northumbria University and Imperial College London has received funding for a novel study that will explore biological, psychological and social factors associated with brain health in female military veterans.
続きを読む »
Discover a New Approach for How to Visualize the Developing Skeleton in 3DThis article from Thermo Fisher Scientific explores how Amira software can be used as a novel approachfor visualizing the developing skeleton in 3D.
続きを読む »
Nintendo developing live-action The Legend of Zelda movieMatt Wales is a writer and gambolling summer child who won't even pretend to live a busily impressive life of dynamic go-getting for the purposes of this bio. He is the sole and founding member of the Birdo for President of Everything Society.
続きを読む »
Researchers solve mystery behind antibiotic-resistant C. difficile infectionResearchers at the Texas A&M University Health Science Center (Texas A&M Health) have uncovered why C. diff (also known as Clostridioides difficile or C. difficile) infection has developed resistance to the antibiotic metronidazole.
続きを読む »