AlphaMissense, a new model from Google’s artificial intelligence team, analyzes the effects of DNA mutations and will accelerate research into rare diseases.
ago, Žiga Avsec was a PhD physics student who found himself taking a crash course in genomics via a university module on machine learning. He was soon working in a lab that studied rare diseases, on a project aiming to pin down the exact genetic mutation that caused an unusual mitochondrial disease.
Of the 4 million missense variants that have been spotted in humans, only 2 percent have been categorized as either pathogenic or benign, through years of painstaking and expensive research. It can take months to study the effect of a single missense variant. Pushmeet Kohli, DeepMind’s vice president of research, uses the analogy of a recipe book. If AlphaFold was concerned with exactly how ingredients might bind together, AlphaMissense predicts what might happen if you use the wrong ingredient entirely.
The researchers stress that the predictions should not be used on their own, but only to guide real-world research: AlphaMissense could help researchers prioritize the slow process of matching genetic mutations to diseases by quickly ruling out unlikely culprits. It could also help improve our understanding of overlooked areas of our genetic code: The model includes an “essentiality” metric for each gene—a measure of how vital it is to human survival.
日本 最新ニュース, 日本 見出し
Similar News:他のニュース ソースから収集した、これに似たニュース記事を読むこともできます。
Expend4bles: 1 New Poster And 1 New International Poster ReleasedTwo new posters for Expend4bles have been released: one from Dolby Cinema and one international poster. It will be released on September 22nd.
続きを読む »
Sylvester Stallone Wore One of Rolex’s New Daytonas to the Premiere of His New DocumentaryThe modern steel reference will set you back $15,100.
続きを読む »
New Shonen Jump Manga is the Fresh New Fantasy More Fans Should Be ReadingShonen Jump's MamaYuyu is great for Fantasy fans.
続きを読む »
White House: Can't Predict if Iran Prisoner Swap Will Incentivize Further Hostage-TakingOn Monday's broadcast of 'CNN News Central,' White House National Security Council Coordinator for Strategic Communications John Kirby responded to a | Clips
続きを読む »
New app will allow New Yorkers to avoid commuting through the poorest air qualityFor those who need to commute when air quality is poor, a new technology will make it possible to use the safest route possible for their health.
続きを読む »
Only Murders in the Building Takes Murder Mystery to New York With New Immersive ExperienceFans of Only Murders in the Building will have the chance to solve Paul Rudd’s murder. (Don’t worry — it’s only Rudd’s Ben Glenroy character from the hit Hulu series.) The streamer will bring the murder mystery to New York City through an immersive investigation experience. According to Variety, the upcoming Only Murders in the […]
続きを読む »