The science behind the 2019 Nobel Prize for Medicine
Share to twitterOtto Warburg, the recipient of the 1931 Nobel Prize in Physiology or Medicine, revealed that oxygen is used by our cells to convert food into energy in an enzymatic process.Three researchers have been awarded the Nobel Prize for Medicine for discovering the complex processes behind how human cells respond to oxygen. William Kaelin Jr, Sir Peter Ratcliffe and Gregg Semenza’s pioneering work is now paving the way for innovative new drugs to defeat cancer and other diseases.
Semenza studied the gene for erythropoietin and found that only one protein-complex called hypoxia-inducible factor both controls how the EPO gene works and also responds to oxygen levels. This protein is present when oxygen levels are low but disappears when they are high.
Already, a number of drugs have been developed on the back of the understanding of this oxygen-sensing pathway. Roxadustat and daprodustat, for example, treat anaemia by increasing red blood cell production, and similar drugs are aiming to treat patients with heart disease and lung cancer that struggle with hypoxia . More experimental drugs are also blocking blood vessel formation, aiming to prevent tumor growth in some cancers.
Randall Johnson, prize committee member and professor of molecular physiology and pathology at Cambridge University, described the trio’s work as a “textbook discovery,” adding “this is something basic biology students will be learning about when they study, at aged 12 or 13. ... This is a basic aspect of how a cell works, and I think from that standpoint alone it’s a very exciting thing.”
The three 2019 laureates, who also won the esteemed Lasker prize in 2016, will now share the 9M Swedish kronor prize, and I get the impression that following a brief celebration, it will be straight back to work. On receiving the 5 a.m. call from Sweden, Ratcliffe told“I tried to make sure it wasn’t some friend down the road having a laugh at my expense.
日本 最新ニュース, 日本 見出し
Similar News:他のニュース ソースから収集した、これに似たニュース記事を読むこともできます。
The life-saving science behind the 2019 Nobel Prize for MedicineThe research could lead to new treatments for potentially deadly conditions including cancer, heart attack, and stroke. - NBCNewsMACH
続きを読む »
Nobel prize for medicine: how oxygen affects cellsThis year’s winners helped explain oxygen-sensitive processes and their effect on cancers, heart attacks and strokes
続きを読む »
Nobel Medicine Prize won by doctors for work on cells' response to oxygenTwo scientists from the United States and one from Britain won the 2019 Nobel Medicine Prize Here is a look at previous and current NobelPrize winners Via ReutersGraphics
続きを読む »
Doctors who deciphered body's response to oxygen win Nobel Medicine PrizeTwo Americans and a Briton won the 2019 Nobel Medicine Prize on Monday for disco...
続きを読む »
The 2019 Nobel Prize In Medicine: Here Is What Won The AwardThe 2019 Nobel Prize in Physiology or Medicine was jointly awarded to three scientists — William G. Kaelin Jr., Peter J. Ratcliffe and Gregg L. Semenza — for their work on how cells sense and adapt to the levels of oxygen.
続きを読む »