An unexpected discovery turned out to be a valuable one.
Dr. Jung-Mo Ahn, Wednesday, Oct. 26, 2022, at the University of Texas at Dallas campus in Richardson. Ahn and his team have synthesized a molecule that can kill a variety of cancer cells. Ahn began working as a professor at UTD in 2004.Researchers from two North Texas universities have created a molecule that kills a spectrum of hard-to-treat cancers, including an aggressive form of breast cancer.
In his lab at UTD, Ahn creates tiny molecules that can have a large impact on how our bodies fight diseases like cancer. He tries to prevent molecular “handshakes” between proteins that lead to uncontrollable cell growth and cancer spread. The researchers altered the molecule’s structure and tested it on breast cancer cells, using TNBC cells as a baseline. They weren’t expecting it to work on the TNBCs – after all, the molecule wasn’t designed to kill those cells.
Healthy cells have less LIPA compared to TNBC cells. The researchers found that ERX-41 successfully killed human cancer cells in mice without significantly harming healthy cells. “I think what was really fascinating was that it was almost a serendipitous discovery of a new target that might be a viable target for therapeutics in cancer,” said del Valle, who was not involved with the study.Ahn and his co-authors are working to develop ERX-41 into a treatment that could be tested in animals, and eventually human patients. The Dallas-based startup EtiraRX, created by Ahn, Raj and Vadlamudi in 2018, has licensed the tech with plans to start clinical trials next year.
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