Using CRISPR to modify certain immune cells could make cancer-fighting immunotherapy more potent for a broader set of patients. Two people who went through the treatment share their stories.
, a gene-editing scientist at the University of California, Berkeley, who was not involved in the research."This field is progressing remarkably fast."But not all researchers are as enthusiastic about the promise of off-the-shelf CAR T-cell treatments. Some point out that this version of the more generic therapy doesn't appear to last as long, and may not be as effective, as the original versions, which rely on a patient's own cells.
, who is doing similar research at the National Cancer Institute."That's a fundamental problem that you cannot completely overcome, no matter what you do."at Memorial Sloan Kettering Cancer Center in New York agrees with Kochenderfer that there's room for improvement. McGuirk and others acknowledge that more research is needed involving more patients to figure out just how well the off-the-shelf approach works, how long it lasts, and how to make the cells last longer and work better.
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