Preliminary results from a Scripps Research and eMed digital medicine study show an unexpectedly high proportion of COVID-19 rebound cases in untreated people, as well as those treated with Paxlovid. “COVID rebound,” in which evidence of the illness disappears and then returns days or weeks later
A study by Scripps Research and eMed digital medicine shows a surprisingly high percentage of COVID-19 rebound cases in both untreated individuals and those treated with Paxlovid.
“These preliminary results suggest that rebound after clearance of SARS-CoV-2 test positivity or COVID-19 symptom resolution is more common than previously reported in both treated and untreated patients,” says study lead author Jay Pandit, MD, an assistant professor and director of Digital Medicine at the Scripps Research Translational Institute. “We’re going to need a larger set of participants and more extended follow-up to better understand this rebound phenomenon.
To help illuminate the rebound phenomenon and any connection to Paxlovid, Pandit and his colleagues teamed up with eMed to drive a “real-world” study of outcomes among people using the company’s COVID-19 Test-to-Treat antigen test kits with telehealth proctoring and telemedicine. Either way rebounds were measured, the Paxlovid group experienced them at a higher rate: 14.2% vs. 9.3% for antigen test rebounds, and 18.9% vs. 7.0% for symptom rebounds. With the small participant numbers included in this preliminary analysis, these differences were not statistically significant. Moreover, on other measures , the two groups had essentially identical outcomes. Age, gender and pre-existing conditions also did not appear to influence rebound.
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