COVID-19 vaccine for children after multisystem inflammatory syndrome appears safe nih_nhlbi jamanetworkopen
was 12.2 years and 73.5% were male. The participants were racially diverse—24.3% were Black, 31.9% were Hispanic, and 28.6% were white. The median length of time from their MIS-C diagnosis to their first vaccine dose was nine months.
"We are very reassured by the results and this safety data should be comforting to families and health care professionals when considering and recommending vaccination," said study co-leader Matthew D. Elias, M.D., a pediatric cardiologist at Children's Hospital of Philadelphia and clinical assistant professor of pediatrics at the University of Pennsylvania, Philadelphia. Audrey Dionne, M.D.
To date, more than 9,000 patients have been diagnosed with MIS-C in the United States, and 74 have died, according to. However, the disease appears to be on the decline, according to studies by others.
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Underlying genetic cause for MIS-C complications after COVID-19 identifiedA recent Science journal study determined the underlying cause of MIS-C related to SARS-CoV-2 in some children. It hypothesized that monogenic inborn errors of immunity (IEI) is the primary reason for this condition. Identifying these inborn errors is expected to help elucidate the disease's cellular, molecular, and immunological basis.
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Genome-Wide Pleiotropy Study Identifies Association of PDGFB with Age-Related Macular Degeneration and COVID-19 Infection OutcomesAge-related macular degeneration (AMD) has been implicated as a risk factor for severe consequences from COVID-19. We evaluated the genetic architecture shared between AMD and COVID-19 (critical illness, hospitalization, and infections) using analyses of genetic correlations and pleiotropy (i.e., cross-phenotype meta-analysis) of AMD (n=33,976) and COVID-19 (n ≥ 1,388,342) and subsequent analyses including expression quantitative trait locus (eQTL), differential gene expression, and Mendelian randomization (MR). We observed a significant genetic correlation between AMD and COVID-19 infection (rG=0.10, p=0.02) and identified novel genome-wide significant associations near PDGFB (best SNP: rs130651; p=2.4 × 10−8) in the pleiotropy analysis of the two diseases. The disease-risk allele of rs130651 was significantly associated with increased gene expression levels of PDGFB in multiple tissues (best eQTL p=1.8 × 10−11 in whole blood) and immune cells (best eQTL p=7.1 × 10−20 in T-cells). PDGFB expression was observed to be higher in AMD cases than AMD controls {fold change (FC)=1.02; p=0.067}, as well as in the peak COVID-19 symptom stage (11–20 days after the symptom onset) compared to early/progressive stage (0–10 days) among COVID-19 patients over age 40 (FC=2.17; p=0.03) and age 50 (FC=2.15; p=0.04). Our MR analysis found that the liability of AMD risk derived from complement system dysfunction {OR (95% CI); hospitalization=1.02 (1.01–1.03), infection=1.02 (1.01–1.03) and increased levels of serum cytokine PDGF-BB {β (95% CI); critical illness=0.07 (0.02–0.11)} are significantly associated with COVID-19 outcomes. Our study demonstrated that the liability of AMD is associated with an increased risk of COVID-19, and PDGFB may be responsible for the severe COVID-19 outcomes among AMD patients.
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Greater Manchester hospitals hit with 'double whammy' of flu and Covid casesIt comes as a leading health official warned pressure on the NHS across the country is now 'equivalent' to the early stages of the pandemic
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UK's high death rates post-Covid could last at least a year, health experts warnHigher numbers of deaths in England and Wales could last for at least two years because of the delayed effects of the Covid pandemic, health experts say
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Australia reviews visa system as it grapples with worker shortage after strict COVID rulesThe country closed its borders during COVID and told foreign students and backpackers to go home. It is now facing the West's second-worst employee shortage after Canada, with some companies offering signing bonuses and flying them in from overseas.
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NHS under more pressure now than at peak of COVID-19 pandemic, leading doctor saysDr Tim Cooksley, president of the Society for Acute Medicine, said 'urgent action' is required to bring the NHS back from the brink.
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