Further investigation through larger studies and extended monitoring is necessary to assess this potential risk. According to a new study published in JAMA Network Open, researchers at Massachusetts General Hospital, a member of Mass General Brigham, discovered that male newborns (but not females)
SARS-CoV-2
Previous research has established connections between other infections during pregnancy and neurodevelopmental disorders in children, such as, but it remains uncertain whether the same holds true for SARS-CoV-2. To shed light on this issue, the researchers analyzed electronic health records of 18,355 live births that occurred during thepandemic, with 883 of these births being to mothers who tested positive for SARS-CoV-2 during pregnancy.
After accounting for race, ethnicity, insurance status, hospital type , maternal age, and preterm status, maternal SARS‐CoV‐2 positivity was associated with a nearly two-fold higher odds of a neurodevelopmental diagnosis at 12 months of age among male children. Maternal SARS‐CoV‐2 positivity was not linked with a higher risk in female children, however.
“The neurodevelopmental risk associated with maternal SARS-CoV-2 infection was disproportionately high in male infants, consistent with the known increased vulnerability of males in the face of prenatal adverse exposures,” says co–lead author Andrea Edlow, MD MSc, an associate professor of Obstetrics, Gynecology, and Reproductive Biology, and a Maternal-Fetal Medicine specialist at MGH.
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