Potential treatment target for rare form of infant epilepsy identified TuftsUniversity sfnjournals
Infantile and epileptic spasms syndrome is a childhood epilepsy syndrome characterized by infantile or late-onset spasms, abnormal neonatal EEG, and epilepsy. Few treatments exist for IESS, clinical outcomes are poor, and the molecular and circuit-level etiologies of IESS are not well understood.
Ns received excessive excitatory input, and their intrinsic ability to fire action potentials was reduced at all time points examined . Subsequently, GABAergic transmission onto pyramidal neurons was uniquely altered in the somatosensory cortex of APC cKO mice at all ages, with both decreased IPSC input at P14 and enhanced IPSC input at P9 and P60.
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