A study has shown that combining adoptive T cell therapy (ACT) with an innovative, personalized cancer vaccine under development can benefit patients with late-stage, drug-resistant ovarian cancer.
A Ludwig Cancer Research study has shown that combining adoptive T cell therapy with an innovative, personalized cancer vaccine under development at the Lausanne Branch of the Ludwig Institute for Cancer Research can benefit patients with late-stage, drug-resistant ovarian cancer.
Though not a double-blind, placebo-controlled trial, the study's findings suggest the benefits of the combination therapy were significant: the median overall survival time of patients who completed the regimen was 14.2 months, compared to a median historical survival of six months or less for comparable patients receiving fourth- and fifth-line chemotherapy.
Patients enrolled in the trial received a therapeutic regimen that was shown to be promising in the previous clinical study. It involves delivering the dendritic cell vaccine along with bevacizumab, a standard ovarian cancer therapy that targets VEGF-A. Aside from promoting blood vessel formation, this factor, secreted by cancer cells, also hampers killer T cell entry into tumors.
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