In November, actor Chris Hemsworth announced that he would be taking a leave from acting to focus on other things after discovering he has a genetic vulnerability to Alzheimer's disease. Here's what to know.
a National Geographic docuseries focusing on ways to slow age-related declines. Hemsworth learned that he has two copies of the APOE4 gene , which is known to increase the risk of Alzheimer’s.
The APOE4 gene codes for a mutated form of APOE and is one of the most significant genetic risk factors for getting Alzheimer’s disease. About 5% of the population has two APOE4 genes, and about 15% of the population carries one copy of the APOE4 gene, says Fillit. Uma Naidoo, MD, director of nutritional and lifestyle psychiatry at Massachusetts General Hospital in Boston, says that with the exception of certain congenital conditions, “our genes may influence ourof developing a certain condition,” but those genes can be “turned on” or “turned off,” depending on things like your environment, lifestyle, and age.Naidoo, who is also a faculty member at Harvard Medical School, stresses that a healthy diet can help stave off cognitive decline and dementia.
A nutrient-dense, anti-inflammatory diet that includes foods rich in probiotics can improve the gut microbiome – the bacteria in the gut – “in a way that resists the development and progression of Alzheimer’s,” Naidoo says. “Research also shows aerobic exercise can increase the volume of the brain, and there is emerging evidence that yoga and tai chi may be protective of the brain in later life, likely in different ways than aerobic exercise,” says Brown, whose research focuses on understanding the role of lifestyle – particularly exercise – in maintaining a healthy aging brain and preventing cognitive decline and dementia.
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