Negative share returns by Chevron Corp. NYSE: $CVX and Microsoft Corp. NASDAQ: $MSFT have been dragging down the Dow Jones Industrial Average in Wednesday's intraday session
Spanish Port Denies Maersk Tanker Entry Over Russian Oil LinksU.S. Shoots Down Iranian-Made Drone Conoco Gas Field In SyriaBiden Administration Pushes A Made-In-America EV Charging NetworkBarclays Vows To Stop Financing Oil Sands ProjectsThe U.S.
May Take Further Action Against Banks Linked To RussiaEuropean Parliament Approves ICE Car BanMassive Crude Build Pressures Oil Prices1 dayNew Treatment Improves Lithium Ion Battery Performance By 20%Australian Court Overturns Natural Gas Exploration BanThe Prices Of Battery Metals Are Set To SlumpIsrael Set To Export Its First-Ever Crude Oil CargoBarclays: Shipping Rates Could Dip Below Pre-Pandemic LevelsRussia To Sell Most Of Its Oil To “Friendly” Countries: NovakBritain’s Pubs Are At A...
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'Worried' Gallas dreading 'negative spiral' that could see Arsenal finish below Man UtdWilliam Gallas is 'worried' for Arsenal on Wednesday night with the former defender predicting 'massive' psychological effects if they lose to Man City.
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Robertson laughs in Pickford's face as s***housery against Everton delights Liverpool fansLiverpool star Andy Robertson was up to his old tricks as his antics sparked a melee on the Anfield pitch during the Merseyside derby. With time running out at Anfield and the Toffees two goals dow…
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The Relationship between Intracranial Pressure and Visual Field Zones in Normal-Tension Glaucoma PatientsGrowing evidence suggests that intracranial pressure (ICP) plays an important role in the pathophysiology of glaucoma, especially in normal-tension glaucoma (NTG) patients. Controversial results exist about ICP’s relationship to visual field (VF) changes. With the aim to assess the relationship between ICP and VF zones in NTG patients, 80 NTG patients (age 59.5 (11.6) years) with early-stage glaucoma were included in this prospective study. Intraocular pressure (IOP) (Goldmann), visual perimetry (Humphrey) and non-invasive ICP (via a two-depth Transcranial Doppler, Vittamed UAB, Lithuania) were evaluated. Translaminar pressure difference (TPD) was calculated according to the formula TPD=IOP − ICP. The VFs of each patient were divided into five zones: nasal, temporal, peripheral, central, and paracentral. The average pattern deviation (PD) scores were calculated in each zone. The level of significance p < 0.05 was considered significant. NTG patients had a mean ICP of 8.5 (2.4) mmHg. Higher TPD was related with lower mean deviation (MD) (p=0.01) and higher pattern standard deviation (PSD) (p=0.01). ICP was significantly associated with the lowest averaged PD scores in the nasal VF zone (p < 0.001). There were no significant correlations between ICP and other VF zones with the most negative mean PD value. (p > 0.05). Further studies are needed to analyze the involvement of ICP in NTG management.
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Variability Among Breast Cancer Risk Classification Models When Applied at the Level of the Individual Woman - Journal of General Internal MedicineBackground Breast cancer risk models guide screening and chemoprevention decisions, but the extent and effect of variability among models, particularly at the individual level, is uncertain. Objective To quantify the accuracy and disagreement between commonly used risk models in categorizing individual women as average vs. high risk for developing invasive breast cancer. Design Comparison of three risk prediction models: Breast Cancer Risk Assessment Tool (BCRAT), Breast Cancer Surveillance Consortium (BCSC) model, and International Breast Intervention Study (IBIS) model. Subjects Women 40 to 74 years of age presenting for screening mammography at a multisite health system between 2011 and 2015, with 5-year follow-up for cancer outcome. Main Measures Comparison of model discrimination and calibration at the population level and inter-model agreement for 5-year breast cancer risk at the individual level using two cutoffs (≥ 1.67% and ≥ 3.0%). Key Results A total of 31,115 women were included. When using the ≥ 1.67% threshold, more than 21% of women were classified as high risk for developing breast cancer in the next 5 years by one model, but average risk by another model. When using the ≥ 3.0% threshold, more than 5% of women had disagreements in risk severity between models. Almost half of the women (46.6%) were classified as high risk by at least one of the three models (e.g., if all three models were applied) for the threshold of ≥ 1.67%, and 11.1% were classified as high risk for ≥ 3.0%. All three models had similar accuracy at the population level. Conclusions Breast cancer risk estimates for individual women vary substantially, depending on which risk assessment model is used. The choice of cutoff used to define high risk can lead to adverse effects for screening, preventive care, and quality of life for misidentified individuals. Clinicians need to be aware of the high false-positive and false-negative rates and variation between models when talking with pati
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Frontiers | Neuroplasticity in F16 fighter jet pilotsExposure to altered g-levels causes unusual sensorimotor demands that must be dealt with by the brain. This study aimed to investigate whether fighter pilots, who are exposed to frequent g-level transitions and high g-levels, show differential functional characteristics compared to matched controls, indicative of neuroplasticity. We acquired resting-state functional magnetic resonance imaging data to assess brain functional connectivity (FC) changes with increasing flight experience in pilots and to assess differences in FC between pilots and controls. We performed whole-brain exploratory and region-of-interest (ROI) analyses, with the right parietal operculum 2 (OP2) and the right angular gyrus (AG) as ROIs. Our results show positive correlations with flight experience in the left inferior and right middle frontal gyri, and in the right temporal pole. Negative correlations were observed in primary sensorimotor regions. We found decreased whole-brain FC of the left inferior frontal gyrus in fighter pilots compared to controls and this cluster showed decreased FC with the medial superior frontal gyrus. FC increased between the right OP2 and the left visual cortex, and between the right left AG in pilots compared to controls. These findings suggest altered motor, vestibular, and multisensory processing in the brains of fighter pilots, possibly reflecting coping strategies to altered sensorimotor demands during flight. Altered FC in frontal areas may reflect adaptive cognitive strategies to cope with challenging conditions during flight. These findings provide novel insights into brain functional characteristics of fighter pilots, which may be of interest to humans traveling to space.
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Childbirth-related post-traumatic stress disorder symptoms and mother–infant neurophysiological and behavioral co-regulation during dyadic interaction: study protocol - BMC PsychologyBackground Mother’s childbirth-related posttraumatic stress disorder (PTSD) symptoms have a negative impact on mother and infant’s behaviors during dyadic interactions which may increase mother–infant neurophysiological and behavioral co-regulation difficulties, leading to dysregulated mother–infant interactions. This study was specifically designed to analyze: (1) the sociodemographic and obstetric factors associated with mother’s childbirth-related PTSD symptoms; (2) mother–infant neurophysiological functioning and behavioral co-regulation during dyadic interaction; (3) the impact of mother’s childbirth-related PTSD symptoms on neurophysiological and behavioral mother–infant co-regulation during dyadic interaction; (4) the moderator role of previous trauma on the impact of mother’s childbirth-related PTSD symptoms on neurophysiological and behavioral mother–infant co-regulation during dyadic interaction; and (5) the moderator role of comorbid symptoms of anxiety and depression on the impact of mother’s childbirth-related PTSD symptoms on neurophysiological and behavioral mother–infant co-regulation during dyadic interaction. Methods At least 250 mothers will be contacted in order to account for refusals and dropouts and guarantee at least 100 participating mother–infant dyads with all the assessment waves completed. The study has a longitudinal design with three assessment waves: (1) 1–3 days postpartum, (2) 8 weeks postpartum, and (3) 22 weeks postpartum. Between 1 and 3 days postpartum, mothers will report on-site on their sociodemographic and obstetric characteristics. At 8 weeks postpartum, mothers will complete online self-reported measures of birth trauma, previous trauma, childbirth-related PTSD, anxiety, and depressive symptoms. At 22 weeks postpartum, mothers will complete online self-reported measures of childbirth-related PTSD, anxiety, and depressive symptoms. Mothers and infants will then be home-visited to observe and record their neurophysiological,
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