CARTcelltherapy may eliminate tumor cells missed by surgery pennmedicine ScienceAdvances
, the researchers applied a special gel containing human CAR T cells to surgical wounds in mice following partial tumor removal. They found that in almost all cases, the CAR T cells apparently eliminated the residual tumor cells—allowing the mice to survive when they otherwise would have succumbed to tumor recurrence.
"As we continue to advance CAR T cell therapy forward, finding applications for use in solid tumors is a major goal," said study senior author Carl June, MD, the Richard W. Vague Professor in Immunotherapy and director of the Center for Cellular Immunotherapies at Penn Medicine's Abramson Cancer Center."Based on the promising results in this study, our colleagues have planned a clinical trial in patients with locally advanced breast cancer.
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