Cancer-fighting antibodies inject chemo directly into tumor cells, upping effectiveness

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Cancer-fighting antibodies inject chemo directly into tumor cells, upping effectiveness
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Berkeley Lovelace Jr. is a health and medical reporter for NBC News. He covers the Food and Drug Administration, with a special focus on Covid vaccines, prescription drug pricing and health care. He previously covered the biotech and pharmaceutical industry with CNBC.

By attaching a chemotherapy drug to an antibody, doctors are able to deliver more potent cancer-fighting medicines directly into tumor cells, all while causing fewer side effects. The chemotherapy-antibody combinations, known as antibody drug conjugates, have been described as both heat-seeking missiles and Trojan horses for cancer cells, designed to specifically home in on a patient’s tumor cells and trick them into engulfing the antibodies, along with their deadly payload.

Fish said she has been feeling great on the new treatment. “I played, two weeks ago, 18 holes of golf, so it’s been pretty darn good,” she said. ‘A clear, clear positive signal’ Fish later learned that she had a subtype of breast cancer called HER2-low, a recently identified form of the disease. Previously, breast cancers had been classified as being either HER2-positive or HER2-negative, depending on whether their tumor cells carried the HER2 molecule.

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