An insight into the cosmology of Bronze Age Britain, right on our doorstep
A woman has been sent to prison for 20 weeks and banned from keeping all animals for 10 years after causing unnecessary suffering to 13 horses.
She was sentenced to 20 weeks immediate custody, banned from keeping all animals for 10 years and ordered to pay £500 costs. Further into the barn was a slightly larger enclosure with fencing approximately 6-7ft high, giving the pen the appearance of a cage. “We are so very grateful to Bransby Horses for taking on such a large number of horses and I am so pleased that they have all thrived since being in their care.”
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Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk - BMC MedicineBackground Observational epidemiological studies suggest a link between several factors related to ovulation and reproductive function and endometrial cancer (EC) risk; however, it is not clear whether these relationships are causal, and whether the risk factors act independently of each other. The aim of this study was to investigate putative causal relationships between the number of live births, age at last live birth, and years ovulating and EC risk. Methods We conducted a series of observational analyses to investigate various risk factors and EC risk in the UK Biobank (UKBB). Additionally, multivariate analysis was performed to elucidate the relationship between the number of live births, age at last live birth, and years ovulating and other related factors such as age at natural menopause, age at menarche, and body mass index (BMI). Secondly, we used Mendelian randomization (MR) to assess if these observed relationships were causal. Genome-wide significant single nucleotide polymorphisms (SNPs) were extracted from previous studies of woman’s number of live births, age at menopause and menarche, and BMI. We conducted a genome-wide association analysis using the UKBB to identify SNPs associated with years ovulating, years using the contraceptive pill, and age at last live birth. Results We found evidence for a causal effect of the number of live births (inverse variance weighted (IVW) odds ratio (OR): 0.537, p = 0.006), the number of years ovulating (IVW OR: 1.051, p = 0.014), in addition to the known risk factors BMI, age at menarche, and age at menopause on EC risk in the univariate MR analyses. Due to the close relationships between these factors, we followed up with multivariable MR (MVMR) analysis. Results from the MVMR analysis showed that number of live births had a causal effect on EC risk (OR: 0.783, p=0.036) independent of BMI, age at menarche and age at menopause. Conclusions MVMR analysis showed that the number of live births causally reduced the ri
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The voice of Batman Kevin Conroy dies age 66 after short battle with cancerActor Kevin Conroy, who voiced the animated version of DC Comics superhero Batman throughout the 90s, has died age 66. The star's death was announced by his loving co-star
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Buccaneers QB Tom Brady Almost Retired at This Age Due to Elbow PainTom Brady briefly retired earlier this year, and in a new video for his TB12 company, the former Patriots quarterback reveals he almost retired at a point much earlier in his career.
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University is wasted on the young and stupid – the minimum age should be 30University is wasted on the young and stupid – the minimum age should be 30 🔵 My new rule: you need 10 years of life and work under your belt before you are allowed to embark on any tertiary education ✍️ Lucy Mangan for ipaperviews
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