The results emphasized the role of body posture and stomach motility in drug bioavailability.
Concerning this, researchers from Johns Hopkins University and Johns Hopkins School of Medicine have conducted a study to examine how body posture and stomach motility affect drug bioavailability.
"However, current experimental or clinical procedures for assessing the dissolution of oral drugs are limited in their ability to study this, which makes it a challenge to understand how the dissolution is affected in different stomach disorders, such as gastroparesis, which slows down the emptying of the stomach."Stomach contents, motility, and gastric fluid dynamics are also influential factors in a drug's bioavailability.
This modeling is the first of its kind to quantify an active pharmaceutical ingredient passing through the pylorus into the duodenum by coupling gastric biomechanics with pill movement and drug dissolution. It can pave the way for researchers to calculate and compare the emptying rate and the release of a dissolved active pharmaceutical ingredient into the duodenum for various physiological situations.
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