Hormone mimics offer advantages even beyond those of the potent weight-loss jabs on the market now.
. Phase II trials provide data on a drug’s efficacy and ideal dosage in a small group of participants.Orforglipron and retatrutide both mimic hormones produced by the lining of the gut in response to certain nutrients. These hormones help to slow the passage of food through the digestive tract and lower appetite by acting on receptors in the brain — both effects that reduce people’s desire to eat and help them to lose weight.
Orforglipron, however, is a non-peptide molecule that’s easy to produce and package into a pill. The drug’s price has not yet been set, but it will probably be much cheaper than existing weight-management drugs, says internal-medicine physician Sean Wharton at McMaster University in Hamilton, Canada. “I see it as a game changer, myself,” says Wharton, who co-authored the orforglipron study.
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