Bats spread viruses

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Bats spread viruses
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Bats' immune systems have unusual features that cause viruses to fight back

-2 leapt from to infect human beings remains unknown. But the evidence suggests that bats were involved at some point—perhaps not as the immediate source of the virus, but probably as the reservoir from which it ultimately came.outbreak, in 2002. Though this was transmitted to people by palm civets, they probably caught it from horseshoe bats ., another coronavirus, is similarly suspected of starting in bats, though the immediate source of human infection is camels.

The idea that this may not be a coincidence has led people to ask if there is something special about bats which encourages the evolution within them of viruses predisposed to jump the species barrier and infect other sorts of animals. At the moment, the evidence is mixed. In favour of the idea is an experiment conducted recently by Cara Brook of the University of California, Berkeley, and published in February in e. This suggests a possible mechanism. Some bats have unusual immune systems, in which an antiviral process known as the interferon pathway is always active, rather than being switched on in response to infection. Dr Brook and her colleagues conducted experiments on cells from bats that have this arrangement and on others which do not .

by Nardus Mollentze and Daniel Streicker of the University of Glasgow. Dr Mollentze and Dr Streicker found that the number of viruses which have passed to people from 11 orders of mammals and birds is pretty much proportional to the number of species in each order. Bats are the second-most diverse mammalian order, after rodents. “It is therefore not surprising”, Dr Mollentze observes, “that as a group they are associated with a large number of viruses.

This study is in line with work done specifically on coronaviruses by Tracey Goldstein of University of California, Davis. In 2017 she and her colleagues published a piece of research in which they had tested for coronaviruses in bats, rodents and primates in 20 countries in Africa, South America and Asia. Individual bat species normally had between one and five types of coronavirus.

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