Researchers find protein in lungs that sticks to COVID virus like Velcro and forms a natural protective barrier against infection.
Lipin Loo, a postdoctoral researcher who worked on the study with Neely, and PhD student Matthew Waller, noted in a statement that "it acts a bit like Velcro, molecular Velcro, in that it sticks to the spike of the virus and then pulls it away from the target cell types."
LRRC15 can stick to the virus and immobilise it, preventing other vulnerable cells from becoming infected in the process. Waller said in a statement that the researchers "found that this receptor also controls antiviral responses, as well as fibrosis, and could link COVID-19 infection with lung fibrosis that occurs during long COVID.
"This discovery allows us to better understand innate immunity that helps to protect us during virus invasion and offers new ways for development of antivirals.""For me, as an immunologist, the fact that there's this natural immune receptor that we didn't know about, that's lining our lungs and blocks and controls virus, that's crazy interesting," Neely said.
"Since this receptor can block COVID-19 infection, and at the same time activate our body’s anti-virus response, and suppress our body’s fibrosis response, this is a really important new gene."
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