An investigative report suggests that lecanemab can raise the risk of severe brain bleeding when taken with a blood thinner.
The treatment is known as lecanemab and is being jointly developed by the pharmaceutical companies Biogen and Eisai. It’s a lab-made antibody intended to go after amyloid beta, a protein that’s believed to play a pivotal role in Alzheimer’s disease. In people with Alzheimer’s, hardy, toxic clumps of amyloid known as plaques form throughout the brain, damaging it over time.
Earlier this September, the companies announced their latest Phase III trial results of lecanemab. Compared to those on placebo, patients taking lecanemab seemed to experience a slower rate of cognitive decline, while also having lower measured levels of amyloid. The findings appeared to be the first time that any anti-amyloid drug had shown clearly significant,
, benefits in large-scale clinical research. But even this apparent success has now been tempered by these reports of fatal complications linked to the drug.As part of their investigation, Science interviewed the woman’s family and doctors. They were also given access to an unpublished case report written by her doctors and asked outside experts to evaluate the findings.
According to the report, the woman had been part of the original 18-month trial of lecanemab, though likely as part of the placebo group. Afterward, she was given the option to start taking lecanemab and agreed to do so. Sometime later, the woman had a stroke, which prompted a trip to the emergency room at the Northwestern University Medical Center in Chicago. She was then given the blood thinner tissue plasminogen activator , a common stroke treatment meant to restore blocked blood flow.
日本 最新ニュース, 日本 見出し
Similar News:他のニュース ソースから収集した、これに似たニュース記事を読むこともできます。
At least two people trapped in airplane stuck in live power lines in MarylandThe plane was stuck about 100 feet above the ground, and the transmission lines remained live, complicating rescue efforts. About 80,000 people in the area are without power.
続きを読む »
LA County reports 5,244 new COVID cases, 21 more virus deaths over 2-day periodCoronavirus infections continue to mount in Los Angeles County, with the health department reporting 5,244 new cases and 21 additional virus-related deaths covering Thursday and Friday.
続きを読む »
Arizona saw an increase in child deaths during 2021The review released earlier this month said Arizona’s child mortality rate increased by 4.7% from 51 deaths per 100,000 children in 2020 to 53.4 deaths per 100,000 children in 2021, The Arizona Republic reported.
続きを読む »
Man Sought in Deaths of Three at Burning Riverside Home Killed in Confrontation With DeputiesA man sought in the killings of three people found in a burning Riverside home was killed in a confrontation with sheriff’s deputies in the Mojave Desert town of Needles, authorities said Saturday.
続きを読む »
1,000 tips but no arrests: Stabbing deaths of 4 Idaho students remains a mysteryMore than 150 people have been interviewed, but authorities gave no indication they were closer to naming a suspect. More than 45 investigators are involved in the murder case. Here's
続きを読む »
Deaths at funeral in Cameroon landslideDozens of people were attending a funeral on a soccer pitch at the base of a 20-metre high soil embankment, which collapsed on top of them, witnesses said.
続きを読む »