Study shows link between brain age and stroke outcomes KeckSchool_USC
Functional outcomes after stroke are strongly related to focal injury measures. However, the role of global brain health is less clear. Here, we examined the impact of brain age, a measure of neurobiological aging derived from whole brain structural neuroimaging, on post-stroke outcomes, with a focus on sensorimotor performance. We hypothesized that more lesion damage would result in older brain age, which would in turn be associated with poorer outcomes.
Greater lesion damage was associated with older brain age , which in turn was associated with poorer outcomes, both in the sensorimotor domain and across multiple domains of function . Brain age mediated 15% of the impact of lesion damage on sensorimotor performance . Greater brain resilience explained why people have better outcomes, given matched lesion damage .We provide evidence that younger brain age is associated with superior post-stroke outcomes and modifies the impact of focal damage.
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