Protective antidote drugs could protect certain gut microbes without interfering with antibiotics’ effectiveness against harmful bacteria. Antibiotics help to fight bacterial infections, but they can also harm the helpful microbes living in the gut, which can have long-lasting health consequences
Researchers have identified protective drugs that can minimize the negative impact of antibiotics on the gut microbiome without affecting their ability to fight harmful bacteria. The study found that certain antibiotics can have long-lasting negative effects on gut bacteria, but combining them with drugs such as anticoagulants and anti-inflammatory medications can protect gut bacteria without compromising the antibiotics’ effectiveness.
Now new research presented at this year’s European Congress of Clinical Microbiology & Infectious Diseases in Copenhagen, Denmark has identified several protective drugs that may lessen the collateral damage caused by antibiotics without compromising their effectiveness against harmful bacteria. Antibiotics can damage these microbial communities, resulting in an imbalance that can lead to recurrent gastrointestinal problems caused byinfections as well as long-term health problems such as obesity, allergies, asthma, and other immunological or inflammatory diseases.species
The results revealed that the majority of gut bacteria had slightly higher MICs than disease-causing bacteria, suggesting that at commonly used antibiotic concentrations, most of the tested gut bacteria would not be affected. The researchers identified several promising drugs including the anticoagulant dicumarol, the gout medication benzbromarone, and two anti-inflammatory drugs, tolfenamicImportantly, these drugs did not compromise the effectiveness of the antibiotics against disease-causing bacteria.
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