Hyperglycemia is the variable that most affects the number of deaths from heart attack PLOSONE
]. Altogether, it has been recognized that there are sex disparities with regard to the prevalence of risk factors and CVD mortality, however it remains yet unclear to what extent the trend of common risk factors is associated with the decrease in CVD mortality in LMICs, such as Brazil. Importantly, there may be some sort of hierarchy among risk factors in which some are more relevant than others to explain the trend in CVD at the population level.
Therefore, we have investigated the association between several common behavioural and metabolic risk factors and CVD using state-level information from 2005 to 2017 in Brazil. In addition, we quantified how much of the decrease in CVD mortality between 2005 and 2017 could be explained by changes in the state-level prevalences of such risk factors.
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Zika Virus Strains and Dengue Virus Induce Distinct Proteomic Changes in Neural Stem Cells and Neurospheres - Molecular NeurobiologyBrain abnormalities and congenital malformations have been linked to the circulating strain of Zika virus (ZIKV) in Brazil since 2016 during the microcephaly outbreak; however, the molecular mechanisms behind several of these alterations and differential viral molecular targets have not been fully elucidated. Here we explore the proteomic alterations induced by ZIKV by comparing the Brazilian (Br ZIKV) and the African (MR766) viral strains, in addition to comparing them to the molecular responses to the Dengue virus type 2 (DENV). Neural stem cells (NSCs) derived from induced pluripotent stem (iPSCs) were cultured both as monolayers and in suspension (resulting in neurospheres), which were then infected with ZIKV (Br ZIKV or ZIKV MR766) or DENV to assess alterations within neural cells. Large-scale proteomic analyses allowed the comparison not only between viral strains but also regarding the two- and three-dimensional cellular models of neural cells derived from iPSCs, and the effects on their interaction. Altered pathways and biological processes were observed related to cell death, cell cycle dysregulation, and neurogenesis. These results reinforce already published data and provide further information regarding the biological alterations induced by ZIKV and DENV in neural cells.
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Timo Glock: Death threats continued for years after Brazil 2008Timo Glock has explained it took several years for threats against him and his family to subside after his role in the 2008 title decider.
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Comparative hospitalization and mortality risk in the US population during the Omicron and Delta periodsComparative hospitalization and mortality risk in the US population during the Omicron and Delta periods CDCgov NIHClinicalCntr COVID19 coronavirus covid Omicron Delta
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Is there any impact of COVID-19 vaccines on the fertility of men and women of reproductive age?Is there any impact of COVID-19 vaccines on the fertility of men and women of reproductive age? Unicatt COVID19 coronavirus covid ferility SARSCoV2 reproductivehealth
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