Most diagnoses of acutemyeloidleukemia are made during January. Here's why:
are made during January. This finding strongly implies that seasonal factors, such as infectious agents or environmental triggers, influence the development or proliferation of the disease, which points to prevention opportunities. This was the conclusion of an international study led by a team from the Jiménez Díaz Foundation University Hospital Health Research Institute in Madrid, Spain, in collaboration with colleagues from the University of Bristol, United Kingdom.
AML is a rare disease yet is responsible for many cancer-related deaths. Mutations that cause AML can occur due to an inherited mutant gene or exposure to certain carcinogens, such as chemotherapy, radiotherapy, ionizing radiation, tobacco, and benzene. These findings are broadly similar to those of a largeby Calip et al., who found a peak of adult AML diagnoses during December and January from 1992 to 2008.
Nine separate time-series decompositions were performed as an initial exploratory analysis on the monthly incidence rates of AML using data for all cases and data for each sex and age group. Nine separate Poisson generalized linear autoregressive moving average models were fitted to evaluate the temporal dynamics in AML incidence using data for all cases, and data for each sex and age group.
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