Researchers at Charité have uncovered a brain network that, when stimulated, can alleviate symptoms. Alzheimer's disease, which is the most common form of dementia, is challenging to treat. A possible therapy is deep brain stimulation delivered by a pacemaker-like device. A team of researchers from
“DBS works very well in patients with Parkinson’s,” he says. “It improves their quality of life significantly.”
The starting point for the current study, which the researchers carried out in close cooperation with multiple partners including the University of Toronto in Canada, was a random observation made within a Canadian study. “In one patient, who was being treated for obesity, deep brain stimulation caused flashbacks – sudden memories of their childhood and adolescence,” says Dr.
Prof. Horn’s research group has specialized in analyzing high-resolution magnetic resonance images of the brain and combining these with computer models to precisely pinpoint the optimal locations for DBS. “The optimal stimulation site seems to be the intersection of two fiber bundles – the fornix and stria terminalis – that connect regions deep in the brain. Both structures have been linked to memory function,” says Prof. Horn.
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