The increasing prevalence of diabetes worldwide has led to a rise in diabetic wounds, such as diabetic foot ulcers, which are challenging to treat and can result in amputation.
Mar 18 2024TranSpread Traditional treatments have limited effectiveness, underscoring the urgent need for innovative solutions.
In diabetic wounds, high glucose levels disrupt normal cellular processes, including autophagy, leading to impaired healing. The study meticulously demonstrated through a series of sophisticated experiments-ranging from molecular analyses in cell cultures to comprehensive wound healing assays in diabetic mouse models-that treatment with these stem cell-derived exosomes restores autophagy, revitalizes skin cells, and accelerates wound closure.
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Novel therapy harnesses stem cell-derived exosomes for diabetic wound healingResearchers unveiled a novel therapy for diabetic wound healing. This research highlights the use of exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells (BMSCs) to significantly enhance wound healing by promoting keratinocyte autophagy.
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