Abrocitinib shows consistent efficacy and safety in patients with moderate-to-severe atopicdermatitis, whether or not they've already been treated with a biologic, researchers report. DermTwitter
, a monoclonal antibody that inhibits interleukin-4 and interleukin-13 cytokine-induced responses, Gooderham said.abrocitinib, an oral once-a-day Janus kinase 1 inhibitor, to treat the disease. The approval came with a black-box warning about increased risk for serious infections, mortality, malignancy, and lymphoproliferative disorders, major adverse cardiovascular events, thrombosis, and laboratory abnormalities.
In the pooled phase 2b and phase 3 JADE MONO-1 and JADE MONO-2 monotherapy trials, patients received once-daily abrocitinib 100 or 200 mg or placebo for 12 weeks. In the phase 3 JADE REGIMEN, which they analyzed separately, eligible patients were enrolled in a 12-week open-label run-in period during which they received an induction treatment of abrocitinib 200 mg once a day.
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