In a paper published in Science China Materials, a research team reports on a novel tetrapeptide, GFFY, which is capable of efficiently crossing the blood-brain barrier (BBB). The tetrapeptide is highly versatile in covalent labeling with Cy5.5 and the resulting Cy5.5-GFFY can self-assemble into nanospheres.
A novel peptide of GFFY capable of efficiently crossing the blood-brain barrier by specific insulin receptor-mediated transcytosis. Credit: Science China Press, a research team reports on a novel tetrapeptide, GFFY, which is capable of efficiently crossing the blood-brain barrier . The tetrapeptide is highly versatile in covalent labeling with Cy5.5 and the resulting Cy5.5-GFFY can self-assemble into nanospheres.
. Amino acid sequence changes would reduce the efficiency of self-assembling peptides in shuttling through the BBB.when conjugated with hydrophobic molecules such as imaging agents Cy7 and ICG, which is beneficial for the development of nanomaterial-based BBB crossing strategies.
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