A leather-based in vitro model for determining the effect of cosmetics on skin microbes Cosmetics Skin Microbiome microbiology prebiotics formulation MDPIOpenAccess hsrheinwaal
By Dr. Priyom Bose, Ph.D.Aug 28 2022Reviewed by Benedette Cuffari, M.Sc. Human skin harbors a wide range of microorganisms, including fungi, bacteria, and viruses. In fact, recent estimates indicate that over 1011 microbial cells could be present on skin surfaces.
Background Numerous prebiotic supplements have been used in cosmetics to promote the growth of beneficial bacteria, such as coagulase-negative Staphylococci, while suppressing Cutibacterium growth. About the study Seven ubiquitous Gram-positive skin bacteria were selected to analyze how they were affected by the tested prebiotic actives. The actives used in this study included plant-based glycerol, diglycerol, glyceryl caprylate, and multifunctional ingredient.
Study findings The possibility of microbial growth or growth inhibition was studied using liquid culture media that contained prebiotic actives at different concentrations. The culture media with a greater optical density at a given time indicated the promotion of bacterial growth. Similarly, cultures with lower ODs indicated bacterial growth inhibition.
Dissimilarity in microbial growth promotion and inhibitory effects might be observed between in vivo and in vitro experiments using similar microbial strains and active ingredients. This is because the complexities of the interaction between bacteria and skin cells cannot be analyzed in a cell-culture-based model.
Although general sera-containing actives exhibited a similar pattern in bacterial colonization, some minor changes and exceptions were observed. As compared to the colonization pattern of serum alone, the addition of actives led to minor alterations, including less pronounced inhibition of S. aureus and a higher rate of C. jeikeium inhibition.
日本 最新ニュース, 日本 見出し
Similar News:他のニュース ソースから収集した、これに似たニュース記事を読むこともできます。
Population-based study: Autoimmune disorders increase risk of cardiovascular diseaseAbout 10% of the population in high income regions like Europe and the United States has been diagnosed with one or multiple autoimmune disorders. Examples are rheumatoid arthritis, psoriasis, systemic sclerosis, lupus erythematosus and type I diabetes. Although earlier research has suggested associations between some of these disorders and a higher risk of cardiovascular disease, these studies were often too small and limited to selected autoimmune or selected cardiovascular conditions to draw conclusive evidence on the necessity of cardiovascular disease prevention among patients with autoimmune disease, until now.
続きを読む »
The pill can hugely impact your motivation levels, according to a new studyNew research suggests your menstrual cycle has a huge impact on your motivation – especially for those of us on the pill.
続きを読む »
China is on track to ultimately overtake the U.S. in outer spaceAs Defense One reports, a new analysis has concluded that, when it comes to playing the long game in space, Beijing may have the U.S. beat
続きを読む »
What is the impact of the SARS-CoV-2 omicron wave in South Africa?A new study has described the transmissibility of SARS-CoV-2, population-level immunity, and impact of omicron wave in South Africa.
続きを読む »
Seven in ten heart attacks & strokes 'could be prevented with better sleep'SEVEN in ten heart attacks and strokes would be prevented if we all got a good night’s sleep, a study suggests. The problems kill 100,000 Brits a year, meaning tens of thousands of lives could be s…
続きを読む »
Increased cannabis intake during the COVID-19 pandemic is associated with worsening of depression symptoms in people with PTSD - BMC PsychiatryBackground Some evidence suggests substance use affects clinical outcomes in people with posttraumatic stress disorder (PTSD). However, more work is required to examine links between mental health and cannabis use in PTSD during exposure to external stressors such as the COVID-19 pandemic. This study assessed mental health factors in individuals with self-reported PTSD to: (a) determine whether stress, anxiety, and depression symptoms were associated with changes in cannabis consumption across the pandemic, and (b) to contrast the degree to which clinically significant perceived symptom worsening was associated with changes in cannabis intake. Method Data were obtained as part of a larger web-based population survey from April 3rd to June 24th 2020 (i.e., first wave of the pandemic in Canada). Participants (N = 462) with self-reported PTSD completed questionnaires to assess mental health symptoms and answered questions pertaining to their cannabis intake. Participants were categorized according to whether they were using cannabis or not, and if using, whether their use frequency increased, decreased, or remained unchanged during the pandemic. Results Findings indicated an overall perceived worsening of stress, anxiety, and depression symptoms across all groups. A higher-than-expected proportion of individuals who increased their cannabis consumption reached threshold for minimal clinically important worsening of depression, X2(3) = 10.795, p = 0.013 (Cramer’s V = 0.166). Conclusion Overall, those who increased cannabis use during the pandemic were more prone to undergo meaningful perceived worsening of depression symptoms. Prospective investigations will be critical next steps to determine the directionality of the relationship between cannabis and depressive symptoms.
続きを読む »