There may be no way around a two-dose regime, which is common for many immunizations given to children.
There's a high likelihood an eventual vaccine will require a two-dose series, a month or so apart, with the possibility of a booster several years later, adding to the complexity and cost of administration and distribution.
Of the more than 100 vaccine candidates in various stages of testing, almost all are expected to be a two-dose regime, said Barry Bloom, an immunologist and professor of public health at the Harvard T.H. Chan School of Public Health in Boston. When the first dose of a vaccine is given, the immune system reacts to something it hasn’t seen before.
A disease like influenza, which is actually comes from multiple strains of flu that continually mutate and sometimes recombine, require updated vaccines every year.vaccines that protect initially likely will be able to serve as boosters to maintain immunity for longer, said Bloom.
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