Some people could have 'very proficient systems for repairing DNA damage or detoxifying cigarette smoke.” 🧬
If you’re worried about lung cancer, then smoking is incredibly dangerous. The chance of a non-smoker developing the disease is roughly one in 6,000. For someone who smokes regularly, the chances skyrocket to one in five or ten.A team of researchers has begun to figure out why. In a small study published Monday in the peer-reviewed journal, they report that smoking appears to drive a predictable increase in the number of cancer-causing mutations in lung cells — but only up to a point.
For decades, researchers didn’t have any way to measure the mutations in lung cells that actually cause lung cancer. Five years ago, researchers at Albert Einstein College of Medicine in New Yorkto overcome technical limitations that had made it impossible to sequence the genome. That is, they figured out how to determine the exact order of the A, T, C, and G molecules of the DNA within a single cell without introducing too many errors in the process.
But there was a surprise in their data. That close correlation between the number of pack years and the number of mutations disappeared at 23 pack years. After that point, the number of mutations stopped increasing.
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