2022: a year in MIS-C research NatRevRheumatol UCSDMedSchool radychildrens children child childhealth Paediatrics Paediatricrheumatology rheumatology
Background MIS-C is characterized by acute hyperinflammation in multiple organ systems in the following weeks of a viral infection, which can be fatal. The clinical manifestations of the syndrome have been well-characterized; however, data on the immunological responses, pathophysiology, and outcomes of the syndrome are limited.
Nature of vascular injury in MIS-C Studies conducted during the initial COVID-19 period indicated vascular pathophysiology, with coronary artery dilation observed on ECG , with serological findings of thrombocytopenia or reduced platelet count and elevated D-dimer levels. The vascular findings were indicative of low-grade coagulation within the blood vessels. However, further assessments indicated that the coronary vessel damage was short-term.
Studies have reported that the human cardiac endothelium expresses ACE2 , the receptors required by SARS-CoV-2 for entry into host cells. However, the endothelial cells do not permit SARS-CoV-2 replication. The finding could justify the sparing effect of the coronary endothelium among MIS-C patients.
Another study evaluated T lymphocyte responses to SARS-CoV-2 peptide pools among children during the subacute MIS-C period. Numerous Vβ21.3-possessing CD4+ lymphocytes and CD8+ lymphocytes were observed; however, the lymphocytes were not a part of the T lymphocyte population activated by SARS-CoV-2. The findings indicated that the T lymphocyte expansion occurs as a response to an antigen unrelated to SARS-CoV-2.
日本 最新ニュース, 日本 見出し
Similar News:他のニュース ソースから収集した、これに似たニュース記事を読むこともできます。
Breen: Hyundai WRC return a forward step after tough 2022Craig Breen says rejoining Hyundai for a partial World Rally Championship campaign this year is a “forward step” after a difficult 2022 campaign with M-Sport.
続きを読む »
Frontier’s share price dives 40% following disappointing F1 Manager 2022 sales | VGCThe company's latest game underperformed during the key shopping season, as did its older games…
続きを読む »
Verstappen found F1 points gap in 2022 ‘a bit surprising’Max Verstappen found his margin of victory over Charles Leclerc and Ferrari in 2022 “a bit surprising” after comfortably wrapping up the world championship.
続きを読む »
Pub up for sale as 'nine bed house' following closure - complete with muralsIt's a huge property - with some very interesting features
続きを読む »
One month after its release, one of our favorite games of 2022 is already $20 offGet the best superhero game in the last 10 years at a surprising discount.
続きを読む »
Group A streptococcal infections increased in England in 2022In a recent study published in the journal Eurosurveillance, researchers investigated the latest increase in cases of invasive group A streptococcal (iGAS) infection among children in England below the age of 15 to understand the clinical presentations of iGAS as well as the incidence of co-infections with respiratory viruses.
続きを読む »