Dr David Johnson shares the highlights of ACG2022 that he found to be the most provocative. GITwitter
. Dupilumab is a fully human monoclonal antibody that blocks a shared receptor component for interleukin-4 and interleukin-13, which are the key drivers for type 2 inflammation with EoE.
It's important to recognize these are all nonresponders to proton pump inhibitors. The majority also had been on a variety of other treatments, including steroids. These are patients who typically have more severe disease. Whether or not this newer agent needs to be used in mild disease remains to be seen. They'll certainly be more to follow on that question soon.
That's something we can start to look at, as perhaps some patients don't want to take medications daily. There's still more to see regarding the frequency and ongoing use. But the take-home message is that on-demand treatment may be back for acid suppression.In a study of an inflammatory bowel medication, intravenous
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