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A new study reveals how cholesterol and inflammation in different types of human brain cells interact with a protein calledReduced levels of ABCA7 in human brain cells may be a trigger for Alzheimer's, and the team thinks their new information could be used to develop treatments.by two of the authors of the current study found that brain ABCA7 levels decrease with age, and people with lower levels are more likely to develop Alzheimer's disease earlier in life.
Weiner and colleagues performed a series of experiments on human microglia, astrocytes, and neuron cell lines cultured in the lab. After removing some cholesterol, they treated the brain cells with It's possible the loss of ABCA7 in Alzheimer's may be due to an abrupt change in cholesterol metabolism, or an inflammatory response.
"The greatest challenge now is to figure out how to measure ABCA7 levels in the brain of living humans," neuroscientist Nicholas LyssenkoThe progressive and devastating effects of Alzheimer's disease on brain structure and function manifest in a wide range of cognitive and behavioral changes over time.
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