– Scientists Discover Potential Way To Disarm a Mysterious Family of Microbial Proteins

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– Scientists Discover Potential Way To Disarm a Mysterious Family of Microbial Proteins
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Researchers from Duke University might have discovered a method to neutralize them, potentially averting $220 billion in yearly agricultural losses. Many of the bacteria that ravage crops and threaten our food supply employ a shared tactic to induce disease: they inject a cocktail of harmful protei

Researchers have identified how certain harmful bacterial proteins, AvrE/DspE, cause diseases in crops by suppressing plants’ immune systems. Using AI predictions, the team found that these proteins create channels in plants, leading to infections, but also discovered nanoparticles that can block these channels, effectively preventing the bacteria from causing harm, which could save the global economy $220 billion lost to plant diseases annually.

Now, thanks to a team effort between three collaborating research groups, they may finally have an answer to how these molecules make plants sick — and a way to disarm them.Researchers in the He lab study key ingredients in this deadly cocktail, a family of injected proteins called AvrE/DspE, that cause diseases ranging from brown spots in beans and bacterial specks in tomatoes to fire blight in fruit trees.

The researchers knew that some members of this family help the bacteria evade the plant’s immune system. But their first glimpse of the proteins’ 3D structure suggested an additional role. This got the researchers thinking: Perhaps bacteria use these proteins to punch a hole in the plant cell membrane, to “force the host for a drink” during infection, He said.

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