According to a recent study, immune responses could potentially be enhanced even in patients who do not exhibit any visible clinical response. A research team has, for the first time, identified and analyzed the process by which immune cells 'see' and react to cancer cells. This provides valuable i
The findings could lead to better, more personalized immunotherapies.
“This is an important step forward in our understanding of what the T-cell responses see in the tumor and how they change over time while they are in the tumor and in circulation in the blood, searching for new tumor cells to attack,” said Cristina Puig-Saus, Ph.D.
The investigators showed that when the immunotherapy is effective, it directs a diverse repertoire of T cells against a small group of selected mutations in a tumor. These T-cell responses expand and evolve during the course of treatment, both within the tumor and in the bloodstream. Patients for whom the therapy fails also present a T-cell response against a similarly reduced number of mutations in the tumor, but those immune responses are less focused, and they do not expand during treatment.
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