New research has found that depression and the risk of depression are linked to different inflammatory proteins in boys and girls.
New research led by the Institute of Psychiatry, Psychology & Neuroscience at King's College London has found that depression and the risk of depression are linked to different inflammatory proteins in boys and girls.
Researchers investigated sex-differences in the relationship between inflammatory proteins and depression. Published in the, the study found that different cytokines were implicated in depression risk and severity in boys compared to girls. The research was part of the IDEA project funded by MQ Mental Health Research.
The findings indicated that there are sex differences between the individual inflammatory proteins that are associated with depression in adolescents. Higher levels of the cytokine interleukin-2 were associated with both increased risk for depression and the severity of depressive symptoms in boys, but not in girls. However, higher levels of IL-6 were associated with severity of depression in girls, but not boys.
"Our findings suggest that inflammation and biological sex may have combined contribution to the risk for depression. We know that adolescence is a key time when many mental disorders first develop and by identifying which inflammatory proteins are linked to depression and how this is different between boys and girls we hope that our findings can pave the way to understanding what happens at this critical time in life.
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