Although people who survive a childhoodcancer are at an increased risk of developing and dying from subsequent cancers, as well as heart disease and stroke, they can reduce this increased risk by following a healthy lifestyle.
Although people who survive a childhood cancer are at an increased risk of developing and dying from subsequent cancers, as well as heart disease and stroke, they can reduce this increased risk by following a healthy lifestyle, say US investigators.
Co-author Yutaka Yasui, Ph.D., and senior author Greg Armstrong, MD, MSCE, both of St. Jude Department of Epidemiology and Cancer Control, and lead author Stephanie Dixon, MD, MPH, St. Jude Department of Oncology. Future research should focus on interventions for modifiable lifestyle and cardiovascular risk factors that"may need to be specifically tailored to survivors, with the goal of reducing chronic disease development" and extending their lifespan, the researchers commented.Childhood cancer has a tremendous success rate: in the United States, the 5-year survival rate is now more than 85%.
The team identified 34,230 survivors who had been treated between January 1, 1970 and December 31, 1999, at 31 institutions in the United States and Canada. Overall, survivors were at an elevated risk of death vs the general population, at a standardized mortality ratio of 5.6. This ratio peaked at 5-9 years after diagnosis at an 18.1-fold increased risk of death compared with the general population.
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